shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance

The mechanisms underlying tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML) patients lacking explanatory BCR-ABL1 kinase domain mutations are incompletely understood. To identify mechanisms of TKI resistance that are independent of BCR-ABL1 kinase activity, we introduced a...

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Библиографические подробности
Опубликовано в: :Blood
Главные авторы: Khorashad, Jamshid S., Eiring, Anna M., Mason, Clinton C., Gantz, Kevin C., Bowler, Amber D., Redwine, Hannah M., Yu, Fan, Kraft, Ira L., Pomicter, Anthony D., Reynolds, Kimberly R., Iovino, Anthony J., Zabriskie, Matthew S., Heaton, William L., Tantravahi, Srinivas K., Kauffman, Michael, Shacham, Sharon, Chenchik, Alex, Bonneau, Kyle, Ullman, Katharine S., O’Hare, Thomas, Deininger, Michael W.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2015
Предметы:
Myeloid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357584/
https://ncbi.nlm.nih.gov/pubmed/25573989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-588855
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