β-Catenin is required for intrinsic but not extrinsic BCR-ABL1 kinase-independent resistance to tyrosine kinase inhibitors in chronic myeloid leukemia

Activation of nuclear β-catenin and expression of its transcriptional targets promotes chronic myeloid leukemia (CML) progression, tyrosine kinase inhibitor (TKI) resistance, and leukemic stem cell self-renewal. We report that nuclear β-catenin plays a role in leukemia cell-intrinsic but not -extrin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Leukemia
Prif Awduron: Eiring, Anna M., Khorashad, Jamshid S., Anderson, David J., Yu, Fan, Redwine, Hannah M., Mason, Clinton C., Reynolds, Kimberly R., Clair, Phillip M., Gantz, Kevin C., Zhang, Tian Y., Pomicter, Anthony D., Kraft, Ira L., Bowler, Amber D., Johnson, Kara, Mac Partlin, Mary, O’Hare, Thomas, Deininger, Michael W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675686/
https://ncbi.nlm.nih.gov/pubmed/26202934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.196
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