β-Catenin is required for intrinsic but not extrinsic BCR-ABL1 kinase-independent resistance to tyrosine kinase inhibitors in chronic myeloid leukemia

Activation of nuclear β-catenin and expression of its transcriptional targets promotes chronic myeloid leukemia (CML) progression, tyrosine kinase inhibitor (TKI) resistance, and leukemic stem cell self-renewal. We report that nuclear β-catenin plays a role in leukemia cell-intrinsic but not -extrin...

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Udgivet i:Leukemia
Main Authors: Eiring, Anna M., Khorashad, Jamshid S., Anderson, David J., Yu, Fan, Redwine, Hannah M., Mason, Clinton C., Reynolds, Kimberly R., Clair, Phillip M., Gantz, Kevin C., Zhang, Tian Y., Pomicter, Anthony D., Kraft, Ira L., Bowler, Amber D., Johnson, Kara, Mac Partlin, Mary, O’Hare, Thomas, Deininger, Michael W.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675686/
https://ncbi.nlm.nih.gov/pubmed/26202934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.196
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