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Predicting volume of distribution with decision tree-based regression methods using predicted tissue:plasma partition coefficients

BACKGROUND: Volume of distribution is an important pharmacokinetic property that indicates the extent of a drug’s distribution in the body tissues. This paper addresses the problem of how to estimate the apparent volume of distribution at steady state (Vss) of chemical compounds in the human body us...

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Publicado en:J Cheminform
Autores principales: Freitas, Alex A, Limbu, Kriti, Ghafourian, Taravat
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer International Publishing 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356883/
https://ncbi.nlm.nih.gov/pubmed/25767566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13321-015-0054-x
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