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Predicting volume of distribution with decision tree-based regression methods using predicted tissue:plasma partition coefficients
BACKGROUND: Volume of distribution is an important pharmacokinetic property that indicates the extent of a drug’s distribution in the body tissues. This paper addresses the problem of how to estimate the apparent volume of distribution at steady state (Vss) of chemical compounds in the human body us...
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| Publié dans: | J Cheminform |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Springer International Publishing
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4356883/ https://ncbi.nlm.nih.gov/pubmed/25767566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13321-015-0054-x |
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