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Predicting volume of distribution with decision tree-based regression methods using predicted tissue:plasma partition coefficients
BACKGROUND: Volume of distribution is an important pharmacokinetic property that indicates the extent of a drug’s distribution in the body tissues. This paper addresses the problem of how to estimate the apparent volume of distribution at steady state (Vss) of chemical compounds in the human body us...
Kaydedildi:
| Yayımlandı: | J Cheminform |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Springer International Publishing
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4356883/ https://ncbi.nlm.nih.gov/pubmed/25767566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13321-015-0054-x |
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