Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics

Primaquine (PQ) metabolism by the cytochrome P450 (CYP) 2D family of enzymes is required for antimalarial activity in both humans (2D6) and mice (2D). Human CYP 2D6 is highly polymorphic, and decreased CYP 2D6 enzyme activity has been linked to decreased PQ antimalarial activity. Despite the importa...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Potter, Brittney M. J., Xie, Lisa H., Vuong, Chau, Zhang, Jing, Zhang, Ping, Duan, Dehui, Luong, Thu-Lan T., Bandara Herath, H. M. T., Dhammika Nanayakkara, N. P., Tekwani, Babu L., Walker, Larry A., Nolan, Christina K., Sciotti, Richard J., Zottig, Victor E., Smith, Philip L., Paris, Robert M., Read, Lisa T., Li, Qigui, Pybus, Brandon S., Sousa, Jason C., Reichard, Gregory A., Marcsisin, Sean R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356838/
https://ncbi.nlm.nih.gov/pubmed/25645856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00015-15
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados