Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics

Primaquine (PQ) metabolism by the cytochrome P450 (CYP) 2D family of enzymes is required for antimalarial activity in both humans (2D6) and mice (2D). Human CYP 2D6 is highly polymorphic, and decreased CYP 2D6 enzyme activity has been linked to decreased PQ antimalarial activity. Despite the importa...

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Potter, Brittney M. J., Xie, Lisa H., Vuong, Chau, Zhang, Jing, Zhang, Ping, Duan, Dehui, Luong, Thu-Lan T., Bandara Herath, H. M. T., Dhammika Nanayakkara, N. P., Tekwani, Babu L., Walker, Larry A., Nolan, Christina K., Sciotti, Richard J., Zottig, Victor E., Smith, Philip L., Paris, Robert M., Read, Lisa T., Li, Qigui, Pybus, Brandon S., Sousa, Jason C., Reichard, Gregory A., Marcsisin, Sean R.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2015
主題:
Pharmacology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356838/
https://ncbi.nlm.nih.gov/pubmed/25645856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00015-15
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