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Trafficking through the Late Endosome Significantly Impacts Candida albicans Tolerance of the Azole Antifungals
The azole antifungals block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of “toxic” sterol intermediates are both thought to compromise plasma membrane function. However, the effects of ergosterol depletion...
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| Publié dans: | Antimicrob Agents Chemother |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4356793/ https://ncbi.nlm.nih.gov/pubmed/25666149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04239-14 |
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