Trafficking through the Late Endosome Significantly Impacts Candida albicans Tolerance of the Azole Antifungals

The azole antifungals block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of “toxic” sterol intermediates are both thought to compromise plasma membrane function. However, the effects of ergosterol depletion...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Luna-Tapia, Arturo, Kerns, Morgan E., Eberle, Karen E., Jursic, Branko S., Palmer, Glen E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Susceptibility
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356793/
https://ncbi.nlm.nih.gov/pubmed/25666149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04239-14
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