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NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival

Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML). Posttranscriptional regulation by microRNAs (miRNAs) can affect the malignant phenotype of AML cells. In this stud...

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Détails bibliographiques
Publié dans:Cell Death Differ
Auteurs principaux: Shah, N M, Zaitseva, L, Bowles, K M, MacEwan, D J, Rushworth, S A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356334/
https://ncbi.nlm.nih.gov/pubmed/25323587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.152
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