The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML

BACKGROUND: CCAAT/enhancer-binding protein-α (CEBPA) is crucial for normal granulopoiesis and is frequently disrupted in acute myeloid leukaemia (AML). Increasing evidence suggests that CEBPA exerts its effects, in parts, by regulating specific microRNAs (miRNAs), as previously shown for miR-223. Th...

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Bibliografische gegevens
Hoofdauteurs: Eyholzer, M, Schmid, S, Wilkens, L, Mueller, B U, Pabst, T
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2010
Onderwerpen:
Genetics and Genomics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906742/
https://ncbi.nlm.nih.gov/pubmed/20628397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605751
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