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Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML
Deregulation of the myeloid key transcription factor CEBPA is a common event in acute myeloid leukemia (AML). We previously reported that the chaperone calreticulin is activated in subgroups of AML patients and that calreticulin binds to the stem loop region of the CEBPA mRNA, thereby blocking CEBPA...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3293752/ https://ncbi.nlm.nih.gov/pubmed/21471526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-304485 |
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