Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML

Deregulation of the myeloid key transcription factor CEBPA is a common event in acute myeloid leukemia (AML). We previously reported that the chaperone calreticulin is activated in subgroups of AML patients and that calreticulin binds to the stem loop region of the CEBPA mRNA, thereby blocking CEBPA...

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Detalhes bibliográficos
Main Authors: Haefliger, Simon, Klebig, Christiane, Schaubitzer, Kerstin, Schardt, Julian, Timchenko, Nikolai, Mueller, Beatrice U., Pabst, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293752/
https://ncbi.nlm.nih.gov/pubmed/21471526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-304485
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