Metabolism-Directed Structure Optimization of Benzimidazole-Based Francisella tularensis Enoyl-Reductase (FabI) Inhibitors

FabI is a potential antibiotic target against Francisella tularensis, which has been classified as a Category A biowarfare agent of high risk to public health. Our previous work demonstrated that N-benzyl benzimidazole compounds possess promising FabI inhibitory activity, but their druggability prop...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Xenobiotica
Main Authors: Zhang, Yan-Yan, Liu, Yong, Mehboob, Shahila, Song, Jin-Hua, Boci, Teuta, Johnson, Michael E., Ghosh, Arun K., Jeong, Hyunyoung
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355941/
https://ncbi.nlm.nih.gov/pubmed/24171690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2013.850553
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki