Llwytho...

Discovery of a novel and potent class of F. tularensis enoyl-reductase (FabI) inhibitors by molecular shape and electrostatic matching

Enoyl-acyl carrier protein (ACP) reductase, FabI, is a key enzyme in the bacterial fatty acid biosynthesis pathway (FAS II). FabI is an NADH-dependent oxidoreductase that acts to reduce enoyl-ACP substrates in a final step of the pathway. The absence of this enzyme in humans makes it an attractive t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hevener, Kirk E., Mehboob, Shahila, Su, Pin-Chih, Truong, Kent, Boci, Teuta, Deng, Jiangping, Ghassemi, Mahmood, Cook, James L., Johnson, Michael E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266168/
https://ncbi.nlm.nih.gov/pubmed/22098466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201168g
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