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Structure of the Francisella tularensis enoyl-acyl carrier protein reductase (FabI) in complex with NAD(+) and triclosan

Enoyl-acyl carrier protein reductase (FabI) catalyzes the last rate-limiting step in the elongation cycle of the fatty-acid biosynthesis pathway and has been validated as a potential antimicrobial drug target in Francisella tularensis. The development of new antibiotic therapies is important both to...

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Bibliografske podrobnosti
Main Authors: Mehboob, Shahila, Truong, Kent, Santarsiero, Bernard D., Johnson, Michael E.
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001642/
https://ncbi.nlm.nih.gov/pubmed/21045289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110039862
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