Human Lymphoid Translocation Fragile Zones Are Hypomethylated and Have Accessible Chromatin

Chromosomal translocations are a hallmark of hematopoietic malignancies. CG motifs within translocation fragile zones (typically 20 to 600 bp in size) are prone to chromosomal translocation in lymphomas. Here we demonstrate that the CG motifs in human translocation fragile zones are hypomethylated r...

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Bibliografske podrobnosti
izdano v:Mol Cell Biol
Main Authors: Lu, Zhengfei, Lieber, Michael R., Tsai, Albert G., Pardo, Carolina E., Müschen, Markus, Kladde, Michael P., Hsieh, Chih-Lin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355534/
https://ncbi.nlm.nih.gov/pubmed/25624348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01085-14
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