Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3

Most head and neck squamous cell carcinomas (HNSCC) exhibit a persistent activation of the PI3K-mTOR signaling pathway. We have recently shown that metformin, an oral antidiabetic drug that is also used to treat lipodystrophy in HIV-infected (HIV+) individuals, diminishes mTOR activity and prevents...

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Vydáno v:Cancer Prev Res (Phila)
Hlavní autoři: Madera, Dmitri, Vitale-Cross, Lynn, Martin, Daniel, Schneider, Abraham, Molinolo, Alfredo A., Gangane, Nitin, Carey, Thomas E., McHugh, Jonathan B., Komarck, Christine M., Walline, Heather M., William, William N., Seethala, Raja R., Ferris, Robert, Gutkind, J. Silvio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355306/
https://ncbi.nlm.nih.gov/pubmed/25681087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0348
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