Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3

Most head and neck squamous cell carcinomas (HNSCC) exhibit a persistent activation of the PI3K-mTOR signaling pathway. We have recently shown that metformin, an oral antidiabetic drug that is also used to treat lipodystrophy in HIV-infected (HIV+) individuals, diminishes mTOR activity and prevents...

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Detalhes bibliográficos
Publicado no:Cancer Prev Res (Phila)
Main Authors: Madera, Dmitri, Vitale-Cross, Lynn, Martin, Daniel, Schneider, Abraham, Molinolo, Alfredo A., Gangane, Nitin, Carey, Thomas E., McHugh, Jonathan B., Komarck, Christine M., Walline, Heather M., William, William N., Seethala, Raja R., Ferris, Robert, Gutkind, J. Silvio
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355306/
https://ncbi.nlm.nih.gov/pubmed/25681087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0348
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