A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA(+) oral cancers

mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the activity of targeted agents. Thus, co-targetin...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Yamaguchi, Kosuke, Iglesias-Bartolomé, Ramiro, Wang, Zhiyong, Callejas-Valera, Juan Luis, Amornphimoltham, Panomwat, Molinolo, Alfredo A., Cohen, Ezra E., Califano, Joseph A., Lippman, Scott M., Luo, Ji, Gutkind, J. Silvio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
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Priority Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905432/
https://ncbi.nlm.nih.gov/pubmed/26882569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7372
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