A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA(+) oral cancers

mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the activity of targeted agents. Thus, co-targetin...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Yamaguchi, Kosuke, Iglesias-Bartolomé, Ramiro, Wang, Zhiyong, Callejas-Valera, Juan Luis, Amornphimoltham, Panomwat, Molinolo, Alfredo A., Cohen, Ezra E., Califano, Joseph A., Lippman, Scott M., Luo, Ji, Gutkind, J. Silvio
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2016
Ämnen:
Priority Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905432/
https://ncbi.nlm.nih.gov/pubmed/26882569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7372
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