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Inhibition of mTOR by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesions

PURPOSE: The activation of Akt/mammalian target of rapamycin (mTOR) pathway represents a frequent event in squamous cell carcinoma (SCC) progression, thus raising the possibility of using specific mTOR inhibitors for the treatment of SCC patients. In this regard, blockade of mTOR with rapamycin prev...

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Detalhes bibliográficos
Main Authors: Amornphimoltham, Panomwat, Leelahavanichkul, Kantima, Molinolo, Alfredo, Patel, Vyomesh, Gutkind, J. Silvio
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407681/
https://ncbi.nlm.nih.gov/pubmed/19073969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0703
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