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mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis

The integrity of the epidermis and mucosal epithelia is highly dependent on resident self-renewing stem cells, which makes them vulnerable to physical and chemical insults compromising the repopulating capacity of the epithelial stem cell compartment. This is frequently the case in cancer patients r...

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Detalhes bibliográficos
Main Authors: Iglesias-Bartolome, Ramiro, Patel, Vyomesh, Cotrim, Ana, Leelahavanichkul, Kantima, Molinolo, Alfredo A., Mitchell, James B., Gutkind, J. Silvio
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477550/
https://ncbi.nlm.nih.gov/pubmed/22958932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.06.007
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