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mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis

The integrity of the epidermis and mucosal epithelia is highly dependent on resident self-renewing stem cells, which makes them vulnerable to physical and chemical insults compromising the repopulating capacity of the epithelial stem cell compartment. This is frequently the case in cancer patients r...

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Autores principales: Iglesias-Bartolome, Ramiro, Patel, Vyomesh, Cotrim, Ana, Leelahavanichkul, Kantima, Molinolo, Alfredo A., Mitchell, James B., Gutkind, J. Silvio
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477550/
https://ncbi.nlm.nih.gov/pubmed/22958932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.06.007
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