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mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis

The integrity of the epidermis and mucosal epithelia is highly dependent on resident self-renewing stem cells, which makes them vulnerable to physical and chemical insults compromising the repopulating capacity of the epithelial stem cell compartment. This is frequently the case in cancer patients r...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Iglesias-Bartolome, Ramiro, Patel, Vyomesh, Cotrim, Ana, Leelahavanichkul, Kantima, Molinolo, Alfredo A., Mitchell, James B., Gutkind, J. Silvio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477550/
https://ncbi.nlm.nih.gov/pubmed/22958932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.06.007
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