Associations Between Biomarkers and Age in the Presenilin 1 E280A Autosomal Dominant Alzheimer Disease Kindred A Cross-sectional Study

IMPORTANCE: Age-associated changes in brain imaging and fluid biomarkers are characterized and compared in presenilin 1 (PSEN1) E280A mutation carriers and noncarriers from the world’s largest known autosomal dominant Alzheimer disease (AD) kindred. OBJECTIVE: To characterize and compare age-associa...

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Publicat a:JAMA Neurol
Autors principals: Fleisher, Adam S., Chen, Kewei, Quiroz, Yakeel T., Jakimovich, Laura J., Gomez, Madelyn Gutierrez, Langois, Carolyn M., Langbaum, Jessica B. S., Roontiva, Auttawut, Thiyyagura, Pradeep, Lee, Wendy, Ayutyanont, Napatkamon, Lopez, Liliana, Moreno, Sonia, Muñoz, Claudia, Tirado, Victoria, Acosta-Baena, Natalia, Fagan, Anne M., Giraldo, Margarita, Garcia, Gloria, Huentelman, Matthew J., Tariot, Pierre N., Lopera, Francisco, Reiman, Eric M.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355261/
https://ncbi.nlm.nih.gov/pubmed/25580592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2014.3314
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