Associations Between Biomarkers and Age in the Presenilin 1 E280A Autosomal Dominant Alzheimer Disease Kindred A Cross-sectional Study

IMPORTANCE: Age-associated changes in brain imaging and fluid biomarkers are characterized and compared in presenilin 1 (PSEN1) E280A mutation carriers and noncarriers from the world’s largest known autosomal dominant Alzheimer disease (AD) kindred. OBJECTIVE: To characterize and compare age-associa...

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發表在:JAMA Neurol
Main Authors: Fleisher, Adam S., Chen, Kewei, Quiroz, Yakeel T., Jakimovich, Laura J., Gomez, Madelyn Gutierrez, Langois, Carolyn M., Langbaum, Jessica B. S., Roontiva, Auttawut, Thiyyagura, Pradeep, Lee, Wendy, Ayutyanont, Napatkamon, Lopez, Liliana, Moreno, Sonia, Muñoz, Claudia, Tirado, Victoria, Acosta-Baena, Natalia, Fagan, Anne M., Giraldo, Margarita, Garcia, Gloria, Huentelman, Matthew J., Tariot, Pierre N., Lopera, Francisco, Reiman, Eric M.
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355261/
https://ncbi.nlm.nih.gov/pubmed/25580592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2014.3314
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