The Alzheimer’s Prevention Initiative composite cognitive test score: Sample size estimates for the evaluation of preclinical Alzheimer’s disease treatments in presenilin 1 E280A mutation carriers

OBJECTIVE: There is a need to identify a cognitive composite that is sensitive to tracking preclinical AD decline to be used as a primary endpoint in treatment trials. METHOD: We capitalized on longitudinal data, collected from 1995 to 2010, from cognitively unimpaired presenilin 1 (PSEN1) E280A mut...

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izdano v:J Clin Psychiatry
Main Authors: Ayutyanont, Napatkamon, Langbaum, Jessica B., Hendrix, Suzanne B., Chen, Kewei, Fleisher, Adam S., Friesenhahn, Michel, Ward, Michael, Aguirre, Camilo, Acosta-Baena, Natalia, Madrigal, Lucìa, Muñoz, Claudia, Tirado, Victoria, Moreno, Sonia, Tariot, Pierre N., Lopera, Francisco, Reiman, Eric M.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331113/
https://ncbi.nlm.nih.gov/pubmed/24816373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4088/JCP.13m08927
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