Interferon α/β enhances the cytotoxic response of MEK inhibition in melanoma

Drugs that inhibit the MAPK pathway have therapeutic benefit in melanoma, but responses vary between patients, for reasons that are still largely unknown. Here we aim at explaining this variability using pre- and post-MEK inhibition transcriptional profiles in a panel of melanoma cell-lines. We foun...

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I publikationen:Mol Cell
Huvudupphovsmän: Litvin, Oren, Schwartz, Sarit, Wan, Zhenmao, Schild, Tanya, Rocco, Mark, Oh, Nul Loren, Chen, Bo-Juen, Goddard, Noel, Pratilas, Christine, Pe’er, Dana
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355234/
https://ncbi.nlm.nih.gov/pubmed/25684207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.12.030
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