Interferon α/β enhances the cytotoxic response of MEK inhibition in melanoma

Drugs that inhibit the MAPK pathway have therapeutic benefit in melanoma, but responses vary between patients, for reasons that are still largely unknown. Here we aim at explaining this variability using pre- and post-MEK inhibition transcriptional profiles in a panel of melanoma cell-lines. We foun...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Litvin, Oren, Schwartz, Sarit, Wan, Zhenmao, Schild, Tanya, Rocco, Mark, Oh, Nul Loren, Chen, Bo-Juen, Goddard, Noel, Pratilas, Christine, Pe’er, Dana
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355234/
https://ncbi.nlm.nih.gov/pubmed/25684207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.12.030
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