Interferon α/β enhances the cytotoxic response of MEK inhibition in melanoma

Drugs that inhibit the MAPK pathway have therapeutic benefit in melanoma, but responses vary between patients, for reasons that are still largely unknown. Here we aim at explaining this variability using pre- and post-MEK inhibition transcriptional profiles in a panel of melanoma cell-lines. We foun...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Litvin, Oren, Schwartz, Sarit, Wan, Zhenmao, Schild, Tanya, Rocco, Mark, Oh, Nul Loren, Chen, Bo-Juen, Goddard, Noel, Pratilas, Christine, Pe’er, Dana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355234/
https://ncbi.nlm.nih.gov/pubmed/25684207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.12.030
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