Lack of Effect of Metformin on Mammary Carcinogenesis in Non-Diabetic Rat and Mouse Models

Epidemiologic studies have shown that diabetics receiving the biguanide metformin, as compared to sulfonylureas or insulin, have a lower incidence of breast cancer. Metformin increases levels of activated AMPK and decreases circulating IGF-1; encouraging its potential use in both cancer prevention a...

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Gepubliceerd in:Cancer Prev Res (Phila)
Hoofdauteurs: Thompson, Matthew D., Grubbs, Clinton J., Bode, Ann M., Reid, Joel M., McGovern, Renee, Bernard, Phillip S., Stijleman, Inge J., Green, Jeffery E., Bennett, Christina, Juliana, M. Margaret, Moeinpour, Fariba, Steele, Vernon E., Lubet, Ronald A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355096/
https://ncbi.nlm.nih.gov/pubmed/25681088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0181-T
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