Lack of Effect of Metformin on Mammary Carcinogenesis in Non-Diabetic Rat and Mouse Models

Epidemiologic studies have shown that diabetics receiving the biguanide metformin, as compared to sulfonylureas or insulin, have a lower incidence of breast cancer. Metformin increases levels of activated AMPK and decreases circulating IGF-1; encouraging its potential use in both cancer prevention a...

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Опубликовано в: :Cancer Prev Res (Phila)
Главные авторы: Thompson, Matthew D., Grubbs, Clinton J., Bode, Ann M., Reid, Joel M., McGovern, Renee, Bernard, Phillip S., Stijleman, Inge J., Green, Jeffery E., Bennett, Christina, Juliana, M. Margaret, Moeinpour, Fariba, Steele, Vernon E., Lubet, Ronald A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355096/
https://ncbi.nlm.nih.gov/pubmed/25681088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0181-T
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