Epithelial NAIPs protect against colonic tumorigenesis

NLR family apoptosis inhibitory proteins (NAIPs) belong to both the Nod-like receptor (NLR) and the inhibitor of apoptosis (IAP) families. NAIPs are known to form an inflammasome with NLRC4, but other in vivo functions remain unexplored. Using mice deficient for all NAIP paralogs (Naip1-6(Δ/Δ)), we...

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發表在:J Exp Med
Main Authors: Allam, Ramanjaneyulu, Maillard, Michel H., Tardivel, Aubry, Chennupati, Vijaykumar, Bega, Hristina, Yu, Chi Wang, Velin, Dominique, Schneider, Pascal, Maslowski, Kendle M.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354369/
https://ncbi.nlm.nih.gov/pubmed/25732303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140474
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