Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis

A chronic inflammatory microenvironment favors tumor progression through molecular mechanisms that are still incompletely defined. In inflammation-induced skin cancers, IL-1 receptor- or caspase-1–deficient mice, or mice specifically deficient for the inflammasome adaptor protein ASC (apoptosis-asso...

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Bibliografiske detaljer
Main Authors: Drexler, Stefan K., Bonsignore, Luca, Masin, Mark, Tardivel, Aubry, Jackstadt, Rene, Hermeking, Heiko, Schneider, Pascal, Gross, Olaf, Tschopp, Jurg, Yazdi, Amir S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494892/
https://ncbi.nlm.nih.gov/pubmed/23090995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209171109
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