A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

Myeloid cells assemble inflammasomes in response to infection or cell damage; cytosolic sensors activate pro–caspase-1, indirectly for the most part, via the adaptors ASC and NLRC4. This leads to secretion of proinflammatory cytokines and pyroptosis. To explore complex formation under physiological...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Schmidt, Florian I., Lu, Alvin, Chen, Jeff W., Ruan, Jianbin, Tang, Catherine, Wu, Hao, Ploegh, Hidde L.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2016
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854733/
https://ncbi.nlm.nih.gov/pubmed/27069117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151790
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