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A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly
Myeloid cells assemble inflammasomes in response to infection or cell damage; cytosolic sensors activate pro–caspase-1, indirectly for the most part, via the adaptors ASC and NLRC4. This leads to secretion of proinflammatory cytokines and pyroptosis. To explore complex formation under physiological...
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| Veröffentlicht in: | J Exp Med |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4854733/ https://ncbi.nlm.nih.gov/pubmed/27069117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151790 |
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