HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase

Hypoxia-inducible factor 1 (HIF-1) mediates many of the systemic and cellular responses to intermittent hypoxia (IH), which is an experimental model that simulates O(2) saturation profiles occurring with recurrent apnea. IH-evoked HIF-1α synthesis and stability are due to increased reactive oxygen s...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nanduri, Jayasri, Vaddi, Damodara Reddy, Khan, Shakil A., Wang, Ning, Makarenko, Vladislav, Semenza, Gregg L., Prabhakar, Nanduri R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353619/
https://ncbi.nlm.nih.gov/pubmed/25751622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119762
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