Xanthine Oxidase Mediates Hypoxia-Inducible Factor-2α Degradation by Intermittent Hypoxia

Sleep-disordered breathing with recurrent apnea produces chronic intermittent hypoxia (IH). We previously reported that IH leads to down-regulation of HIF-2α protein via a calpain-dependent signaling pathway resulting in oxidative stress. In the present study, we delineated the signaling pathways as...

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Main Authors: Nanduri, Jayasri, Vaddi, Damodara Reddy, Khan, Shakil A., Wang, Ning, Makerenko, Vladislav, Prabhakar, Nanduri R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790816/
https://ncbi.nlm.nih.gov/pubmed/24124516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075838
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