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Hypoxia-inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia
The role of hypoxia-inducible factor (HIF)-1 in pancreatic β-cell response to intermittent hypoxia (IH) was examined. Studies were performed on adult wild-type (WT), HIF-1α heterozygous (HET), β-cell-specific HIF-1(−/−) mice and mouse insulinoma (MIN6) cells exposed to IH patterned after blood O(2)...
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| Publié dans: | Am J Physiol Cell Physiol |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7789966/ https://ncbi.nlm.nih.gov/pubmed/32936698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00309.2020 |
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