Hypoxia-inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia

The role of hypoxia-inducible factor (HIF)-1 in pancreatic β-cell response to intermittent hypoxia (IH) was examined. Studies were performed on adult wild-type (WT), HIF-1α heterozygous (HET), β-cell-specific HIF-1(−/−) mice and mouse insulinoma (MIN6) cells exposed to IH patterned after blood O(2)...

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Veröffentlicht in:Am J Physiol Cell Physiol
Hauptverfasser: Wang, Ning, Shi, Xue-Feng, Khan, Shakil A., Wang, Benjamin, Semenza, Gregg L., Prabhakar, Nanduri R., Nanduri, Jayasri
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789966/
https://ncbi.nlm.nih.gov/pubmed/32936698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00309.2020
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