Allosteric and hyperekplexic mutant phenotypes investigated on an α(1) glycine receptor transmembrane structure

The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating inhibitory transmission in the nervous system. Its transmembrane domain (TMD) is the target of allosteric modulators such as general anesthetics and ethanol and is a major locus for hyperekplexic congenital mutati...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Moraga-Cid, Gustavo, Sauguet, Ludovic, Huon, Christèle, Malherbe, Laurie, Girard-Blanc, Christine, Petres, Stéphane, Murail, Samuel, Taly, Antoine, Baaden, Marc, Delarue, Marc, Corringer, Pierre-Jean
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352774/
https://ncbi.nlm.nih.gov/pubmed/25730860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417864112
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