Induction of CYP26A1 by Metabolites of Retinoic Acid: Evidence That CYP26A1 Is an Important Enzyme in the Elimination of Active Retinoids

All-trans-retinoic acid (atRA), the active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). The primary hydroxylated metabolites formed from atRA by CYP26A1, and the subsequent metabolite 4-oxo-atRA, bind to RARs and potentially have biologic...

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Bibliographic Details
Published in:Mol Pharmacol
Main Authors: Topletz, Ariel R., Tripathy, Sasmita, Foti, Robert S., Shimshoni, Jakob A., Nelson, Wendel L., Isoherranen, Nina
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352583/
https://ncbi.nlm.nih.gov/pubmed/25492813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.096784
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