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Apc and p53 interaction in DNA damage and genomic instability in hepatocytes
Disruption of Apc within hepatocytes activates Wnt signaling, perturb differentiation and ultimately lead to neoplasia. Apc negatively regulates Wnt signaling but is also involved in organizing the cytoskeleton and may play a role in chromosome segregation. In vitro studies have implicated Apc in th...
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| 出版年: | Oncogene |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4351894/ https://ncbi.nlm.nih.gov/pubmed/25347740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.342 |
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