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Apc and p53 interaction in DNA damage and genomic instability in hepatocytes
Disruption of Apc within hepatocytes activates Wnt signaling, perturb differentiation and ultimately lead to neoplasia. Apc negatively regulates Wnt signaling but is also involved in organizing the cytoskeleton and may play a role in chromosome segregation. In vitro studies have implicated Apc in th...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4351894/ https://ncbi.nlm.nih.gov/pubmed/25347740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.342 |
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