Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

Oncogenic mutations in the K-ras gene occur in ≈50% of human colorectal cancers. However, the precise role that K-ras oncogenes play in tumor formation is still unclear. To address this issue, we have conditionally expressed an oncogenic K-ras(V12) allele in the small intestine of adult mice either...

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Главные авторы: Sansom, Owen J., Meniel, Valerie, Wilkins, Julie A., Cole, Alicia M., Oien, Karin A., Marsh, Victoria, Jamieson, Thomas J., Guerra, Carmen, Ashton, Gabrielle H., Barbacid, Mariano, Clarke, Alan R.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2006
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599922/
https://ncbi.nlm.nih.gov/pubmed/16959882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604130103
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