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Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo
Oncogenic mutations in the K-ras gene occur in ≈50% of human colorectal cancers. However, the precise role that K-ras oncogenes play in tumor formation is still unclear. To address this issue, we have conditionally expressed an oncogenic K-ras(V12) allele in the small intestine of adult mice either...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1599922/ https://ncbi.nlm.nih.gov/pubmed/16959882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604130103 |
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