B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver

Dysregulated Wnt signaling is seen in approximately 30% of hepatocellular carcinomas; thus, finding pathways downstream of the activation of Wnt signaling is key. Here, using cre-lox technology, we deleted the Apc gene in the adult mouse liver and observed a rapid increase in nuclear β-catenin and c...

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Bibliografiske detaljer
Main Authors: Reed, Karen R., Athineos, Dimitris, Meniel, Valerie S., Wilkins, Julie A., Ridgway, Rachel A., Burke, Zoé D., Muncan, Vanesa, Clarke, Alan R., Sansom, Owen J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596219/
https://ncbi.nlm.nih.gov/pubmed/19033191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805778105
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