The Inotropic Effect of the Active Metabolite of Levosimendan, OR-1896, Is Mediated through Inhibition of PDE3 in Rat Ventricular Myocardium

AIMS: We recently published that the positive inotropic response (PIR) to levosimendan can be fully accounted for by phosphodiesterase (PDE) inhibition in both failing human heart and normal rat heart. To determine if the PIR of the active metabolite OR-1896, an important mediator of the long-term c...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Ørstavik, Øivind, Manfra, Ornella, Andressen, Kjetil Wessel, Andersen, Geir Øystein, Skomedal, Tor, Osnes, Jan-Bjørn, Levy, Finn Olav, Krobert, Kurt Allen
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349697/
https://ncbi.nlm.nih.gov/pubmed/25738589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115547
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