Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart

BACKGROUND AND PURPOSE: Levosimendan is known as a calcium sensitizer, although it is also known to inhibit PDE3. We aimed to isolate each component and estimate their contribution to the increased cardiac contractility induced by levosimendan. EXPERIMENTAL APPROACH: Contractile force was measured i...

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Publicat a:Br J Pharmacol
Autors principals: Ørstavik, Ø, Ata, S H, Riise, J, Dahl, C P, Andersen, G Ø, Levy, F O, Skomedal, T, Osnes, J-B, Qvigstad, E
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294032/
https://ncbi.nlm.nih.gov/pubmed/24547784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12647
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