Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart

BACKGROUND AND PURPOSE: Levosimendan is known as a calcium sensitizer, although it is also known to inhibit PDE3. We aimed to isolate each component and estimate their contribution to the increased cardiac contractility induced by levosimendan. EXPERIMENTAL APPROACH: Contractile force was measured i...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Br J Pharmacol
Glavni autori: Ørstavik, Ø, Ata, S H, Riise, J, Dahl, C P, Andersen, G Ø, Levy, F O, Skomedal, T, Osnes, J-B, Qvigstad, E
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Research Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294032/
https://ncbi.nlm.nih.gov/pubmed/24547784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12647
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items