The Inotropic Effect of the Active Metabolite of Levosimendan, OR-1896, Is Mediated through Inhibition of PDE3 in Rat Ventricular Myocardium

AIMS: We recently published that the positive inotropic response (PIR) to levosimendan can be fully accounted for by phosphodiesterase (PDE) inhibition in both failing human heart and normal rat heart. To determine if the PIR of the active metabolite OR-1896, an important mediator of the long-term c...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Ørstavik, Øivind, Manfra, Ornella, Andressen, Kjetil Wessel, Andersen, Geir Øystein, Skomedal, Tor, Osnes, Jan-Bjørn, Levy, Finn Olav, Krobert, Kurt Allen
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349697/
https://ncbi.nlm.nih.gov/pubmed/25738589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115547
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