The Inotropic Effect of the Active Metabolite of Levosimendan, OR-1896, Is Mediated through Inhibition of PDE3 in Rat Ventricular Myocardium

AIMS: We recently published that the positive inotropic response (PIR) to levosimendan can be fully accounted for by phosphodiesterase (PDE) inhibition in both failing human heart and normal rat heart. To determine if the PIR of the active metabolite OR-1896, an important mediator of the long-term c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ørstavik, Øivind, Manfra, Ornella, Andressen, Kjetil Wessel, Andersen, Geir Øystein, Skomedal, Tor, Osnes, Jan-Bjørn, Levy, Finn Olav, Krobert, Kurt Allen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349697/
https://ncbi.nlm.nih.gov/pubmed/25738589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115547
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