The Inotropic Effect of the Active Metabolite of Levosimendan, OR-1896, Is Mediated through Inhibition of PDE3 in Rat Ventricular Myocardium

AIMS: We recently published that the positive inotropic response (PIR) to levosimendan can be fully accounted for by phosphodiesterase (PDE) inhibition in both failing human heart and normal rat heart. To determine if the PIR of the active metabolite OR-1896, an important mediator of the long-term c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Ørstavik, Øivind, Manfra, Ornella, Andressen, Kjetil Wessel, Andersen, Geir Øystein, Skomedal, Tor, Osnes, Jan-Bjørn, Levy, Finn Olav, Krobert, Kurt Allen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349697/
https://ncbi.nlm.nih.gov/pubmed/25738589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115547
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